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Courses

Cancer microenvironment

The course surveys of the essential traits of a malignant cell and the involvement of the cancer microenvironment in their acquisition. The signaling pathways between the cancer cells and their immediate and remote surroundings is reviewed. Examples from both solid and hematological tumors are presented. Special attention to historical context is awarded and the future directions are highlighted and discussed. Course contents are up to date and include the most recent and developing aspects as well.

Contact Me

Prof. Liat Drucker

Email: druckerl@clalit.org.il
Tel: 972-9-7472466

Kfar Saba, Israel

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Select Publications

Exp Cell Res: 444(2):114395, 2025

Ribosomal proteins as distinct “passengers” of microvesicles: new semantics in myeloma and mesenchymal stem cells’ communication

Translational Research. 2021 Oct 236:117-132

Multiple myeloma BM-MSCs increase the tumorigenicity of MM cells via transfer of VLA4-enriched microvesicles

Carcinogenesis. 2020 Mar 13;41(1):100-110

BM-MSCs-derived ECM modifies multiple myeloma phenotype and drug response in a source-dependent manner

Transl Res. 2019 May;207:83-95.

 doi: 10.1016/j.trsl.2019.01.003.

Niche origin of mesenchymal stem cells derived microvesicles determines opposing effects on NSCLC: Primary versus metastatic

Cell Signal. 2020 Jan;65:109456.

 doi: 10.1016/j.cellsig.2019.109456

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Autophagy. 2016;12(1):1-222.

 doi: 10.1080/15548627.2015.1100356.

Mesenchymal stem cells secretomes' affect multiple myeloma translation initiation

Cell Signal. 2016 Jun;28(6):620-30.

 doi: 10.1016/j.cellsig.2016.03.003

The effect of mesenchymal stem cells' secretome on lung cancer progression is contingent on their origin: primary or metastatic niche

Lab Invest. 2018 Dec;98(12):1549-1561.

 doi: 10.1038/s41374-018-0110-z

Multiple myeloma cells promote migration of bone marrow mesenchymal stem cells by altering their translation initiation

J Leukoc Biol. 2016 Oct;100(4):761-770.

 doi: 10.1189/jlb.3A1115-510RR.

Multiple myeloma and bone marrow mesenchymal stem cells' crosstalk: Effect on translation initiation

Mol Carcinog. 2016 Sep;55(9):1343-54

Microvesicles derived from normal and multiple myeloma bone marrow mesenchymal stem cells differentially modulate myeloma cells' phenotype and translation initiation

Carcinogenesis. 2017 Jul 1;38(7):708-716

Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation

Tumour Biol. 2016 Apr;37(4):4755-65

Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma

Cell Signal. 2014 Sep;26(9):1878-87

eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling

Oncotarget. 2015 Feb 28;6(6):4315-29

Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E

Int J Oncol. 2015 Feb;46(2):860-70

Reduced elastin in multiple myeloma niche promotes cell proliferation
Myeloma mesenchymal stem cells' bioenergetics afford a novel selective therapeutic target

Oncogenesis 14(1):9, doi: 10.1038/s41389-025-00554-5, 2025

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