Drucker's Lab

Meir Medical Center and Department of Pathology, Gray Faculty of Medical & Health Sciences, TAU

Our mission

Our research group studies human cancer with emphasis on the malignant cells' interaction with their microenvironment. We aim to characterize the crosstalk between multiple myeloma cells and the bone marrow mesenchymal stem cells that surround them. It is our purpose to identify niche biomarkers for myeloma progression and new therapeutic targets. On this quest, we make a point to strive for excellence and knowledge persistently and enjoy the journey.

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Latest Publication

Myeloma mesenchymal stem cells' bioenergetics afford a novel selective therapeutic target

In this study Oded Komemi showed as part of his Ph.D. that multiple myeloma mesenchymal stem cells are characterized with a different bioenergetic profile compared to normal counterparts. By targeting the specific characteristics, it is possible to mitigate the support of the tumor microenvironment and increase specific drug response.

Meir Medical Center Annual Meeting 2020

Excellent study

Composition of bone marrow mesenchymal stem cells' extracellular matrix as a therapeutic target in multiple myeloma

M Zoabi, M Lishner, M Pasmanik-Chor, Y S Brin, S Tartakover-Matalon, O Jarchowsky-Dolberg, L Drucker

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Drucker's Lab

Our mission

Latest Publication

News and Updates

Meir Medical Center Annual Meeting 2020

Select Publications

Ribosomal proteins as distinct “passengers” of microvesicles: new semantics in myeloma and mesenchymal stem cells’ communication

Multiple myeloma BM-MSCs increase the tumorigenicity of MM cells via transfer of VLA4-enriched microvesicles

BM-MSCs-derived ECM modifies multiple myeloma phenotype and drug response in a source-dependent manner

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

The effect of mesenchymal stem cells' secretome on lung cancer progression is contingent on their origin: primary or metastatic niche

Multiple myeloma cells promote migration of bone marrow mesenchymal stem cells by altering their translation initiation

Multiple myeloma and bone marrow mesenchymal stem cells' crosstalk: Effect on translation initiation

Microvesicles derived from normal and multiple myeloma bone marrow mesenchymal stem cells differentially modulate myeloma cells' phenotype and translation initiation

Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation

Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma

eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling

Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E